RESEARCH ARTICLES/Studies made simple for you.
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Ingredients in our baby skin care look simple but each of them have been added after careful contemplation.
The Efficacy of a Ceramide-based Cream in Mild-to-moderate Atopic Dermatitis
In 2018 there was a study to see the efficiency of ceramides J Clin Aesthet Dermatol. 2018;11(5):30–32.
Use of the ceramide cream resulted in a 100-percent improvement in IGA scores and a 67-percent improvement in overall subject skin assessment scores after four weeks of use in individuals with sensitive skin conditions.
The goal of this study was to determine if a therapeutic cream containing PC-104 synthetic ceramides and other ingredients could help to ameliorate signs and symptoms of mild-to moderate atopic dermatitis and other xerotic or pruritic dermatoses.
Synthetic ceramide combination PC-104 could augment the natural barrier function.2 However, the function of ceramides can be augmented with anti-inflammatory an antibacterial derivatives Hence addition of vitamin e helps in its efficiency
Topical Delivery of Vitamin D3: A Randomized Controlled Pilot Study
Mir Sadat-Ali, Dalal A Bubshait, Haifa A Al-Turki, Dakheel A Al-Dakheel, Wissam S Al-Olayani
The purpose of the present study is to explore the assessment if the transdermal delivery of vitamin D is feasible in 48 women
Our study shows that our formulation of vitamin D3 can safely and effectively be delivered by dermal route reducing the incidence of non-compliance of oral route.
Punica granatum L. (Pomegranate) Extracts and Their Effects on Healthy and Diseased Skin Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozara Markovica St., 34000 Kragujevac, Serbia 2004
in another study, it has been shown that the PG peel has the highest concentrations of gallic and ellagic acids, while punicalagins a and b contributed most to the phenolic content in pomegranate juiceEllagic acid, gallic acid and punicalagins a and b, obtained from the ethyl acetate fraction of the ethanol extract from the entire fruit, demonstrated potential inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE-2) and interleukin-6 (IL-6) production Thus, these compounds may play a role in the anti-inflammatory properties associated with PG.
RESEARCH ABOUT DIFFERENT SEED BUTTERS AND PLANT OILS
Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils 2017
1.Avocado :
Avocado oil is derived from the fruit of the Persea americana. Avocado oil extracted from the pulp of the fruit is rich in linoleic acid (6.1–22.9%), linolenic acid (0.4–4.0%), and oleic acid (31.8–69.6%). It also contains β-sitosterol, β-carotene, lecithin, minerals, and vitamins A, C, D, and E . It is an excellent source of enrichment for dry, damaged, or chapped skin
Coconut oil is extracted from the kernel or meat of mature coconuts harvested from the coconut palm (Cocos nucifera). Coconut is composed of many FFAs including lauric acid (49%), myristic acid (18%), palmitic acid (8%), caprylic acid (8%), capric acid (7%), oleic acid (6%), linoleic acid (2%), and stearic acid (2%) [ Coconut oil has been shown to be as effective and safe as mineral oil when applied as moisturizers for mild to moderate xerosis In a study of pediatric patients with mild to moderate AD, topical applications of virgin coconut oil was shown to be effective in decreasing the severity of the disease, ameliorating disease severity index (SCORAD), and improving barrier function (TEWL and skin capacitance) Topical applications of virgin coconut oil are effective in promoting WH through faster epithelization. A histopathological study by Nevin et al. revealed increased neovascularization, fibroblast proliferation, pepsin-soluble collagen synthesis, and turnover of collagen in wounds Kim et al. demonstrated that coconut oil increased expression of CE components, thereby contributing to protective barrier functions of the SC Furthermore, the expression of inflammatory profile was lower in the coconut oil-treated group after exposure to UVB radiation Topical coconut oil protects the skin from UV radiation Of all the acid components of coconut oil, monolaurin has been shown to have additional significance. Monolaurin is a monoglyceride derived from lauric acid.It comprises nearly 50% of coconut’s fat content. Monolaurin displays antimicrobial activity by disintegrating the lipid membrane of lipid-coated bacteria including Propionibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis Coconut oil in concentrations of 5% to 40% (w/w) exhibited bactericidal activity against Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, and Bacillus subtilis Cellular studies have also shown that monolaurin exhibits antiviral and antifungal activity
2. Safflower Seed Oil
Safflower seed oil comes from the seeds of the Carthamus tinctorius. It contains a large amount of the polyunsaturated linoleic acid (70%) and monounsaturated oleic acid (10%), and lesser amounts of stearic acid. Safflower has been shown to be a very good analgesic and antipyretic. Modern pharmacological studies demonstrated that the extracts of safflower had several physiological functions, such as anticoagulation, vasodilation, antioxidation, melanin production inhibition, immunosuppression, and antitumor activity. For example, the flavone luteolin and its glucopyranoside have been reported to exert anti-inflammatory effects at concentrations in the low micromolar range This anti-inflammatory effect is explained by inhibition of NF-κB activity Fatty acid constituents of topical applied plant oils may modify the fatty acid profiles of the babies. Solanki et al. have showed that topically applied safflower seen oil is readily absorbed in neonates and probably it has nutritional benefits Fatty acid profiles showed significant rise in linolenic acid and arachidonic acid under topical safflower oil treatment Since the metabolism of PUFAs by skin epidermal enzymes is related to the generation of anti-inflammatory molecules, the modification in fatty acid profiles might be of interest in clinical
3. Argan Oil
Argan oil is produced from the kernels of Argania spinosa L. Argan oil is composed of mono-unsaturated (80%) and saturated (20%) fatty acids. It contains polyphenols, tocopherols, sterols, squalene, and triterpene alcohols. Traditionally, argan oil has been utilized in cooking, in the treatment of skin infections, and in skin/hair care products. Daily topical application of argan oil has also been shown to improve skin elasticity and skin hydration by restoring the barrier function and maintaining the water-holding capacity Additionally, topical applications onto skin provide a softening and relaxing effect on the skin, as well as helping to facilitate the accumulation and transdermal delivery of topical drugs such as allantoin .
Recently, tocopherol-rich argan oil-based nanoemulsions has been developed as vehicles possessing anticancer activity in murine breast and colon carcinoma cells Argan oil has also been shown to be effective in enhancing WH created second-degree burns in rats .
4. Oat
Oat oil originates from Avena sativa. It consists of 36–46% linoleic and 28–40% oleic acid Oat in colloidal form is a centuries-old topical treatment for a variety of skin conditions, including skin rashes, erythema, burns, itch, and eczema. Although oleic acid may disrupt skin barrier, the high percentage (36–46%) of linoleic acid may contribute to the final effect of oat oil on barrier repair Colloidal oat extracts exhibit direct anti-oxidant and anti-inflammatory activities, which may explain the efficacy of lotions containing colloidal oatmeal Avenanthramides are phenolic compounds present in oats. Avenanthramides inhibit activation of NF-κB and reduce inflammation by inhibiting cytokines In vitro studies have shown that oat oil can upregulate the expression of differentiation genes (e.g., involucrin, small prolin-rich protein family (SPRRs), and transglutaminase 1) and ceramide processing genes (β-glucocerebrosidase, sphingomyelinases 3 and ABCA12) in keratinocytes . In addition, oat oil treatment in keratinocytes was shown to have significantly increased ceramide levels (70%) through the activation of peroxisome proliferator-activated receptors (PPARs)
5.Pomegranate Seed Oil
Pomegranate seed oil comes from the seed of Punica granatum. It is a good source of essential FFAs, phenolic compounds, phytosterols, and lipid-soluble fractions . Pomegranate seed oil contains 63% UFA, including linoleic acid (29%) and oleic acid (10%) Pomegranate seed oil is well known for its high concentration of polyphenolic compounds and for its antioxidant and anti-inflammatory properties. An oil-in-water cream containing pomegranate seed oil and C. lechleri resin extract can be helpful in the prevention or improvement of skin changes associated with striae [ Pomegranate seed oil has been used in nanoemulsions to facilitate the delivery of pomegranate peel polyphenols . Nanoemulsions with pomegranate seed oil has been shown to improve both photostability and in vivo anti-nociceptive effect of ketoprofen . A study of CD1 mice with topically applied pomegranate seed oil has shown that pomegranate seed oil (5%) significantly decreased tumor incidence and 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ornithine decarboxylase activity in the chemical-induced skin cancer model. The results highlighted the potential of pomegranate seed oil as a chemopreventive agent against skin cancer
6 Almond Oil
Almond oil comes from Oleum amygdalae. Almond oil has emollient and sclerosant properties, which have been used to improve complexion and skin tone. In a nonrandomized study, Tashan and Kafkasli (2012) have demonstrated that massage with bitter almond oil may be effective in reducing the visibility of current striae gravidarum, and in the prevention of new striae Other formulations have been shown to ameliorate striae itching . However, other products containing almond oil have not shown to have similar benefit . For example, sweet almond oil in creams are more effective than the base cream at ameliorating the itching of striae and preventing its progression . In a study by Sultana et al. done with murine models, topical almond oil was shown to prevent the structural damage caused by UV irradiation .
Can we use baby products for older kids as well?
You’re absolutely right—baby products are often a great choice for older kids because they are specifically formulated to be gentle, non-irritating, and free from the harsh chemicals often found in adult "big kid" toiletries.
However, as kids grow, their skin and hair needs do change. Here is a breakdown of when baby products are perfect and when you might want to consider a "middle ground" kids' product.
Why Baby Products Work Well
- Hypoallergenic: Most baby lotions and washes are free of parabens, phthalates, and strong synthetic fragrances, making them ideal for kids with sensitive skin or eczema.
- Tear-Free Formulas: Many school-aged kids still struggle with soap in their eyes. Baby shampoos use milder surfactants that don't sting, which can make bath time much less stressful.
- pH Balanced: Baby products are designed to protect the "acid mantle" (the skin's natural barrier), which is still developing in children up to age 12.
When to Make the Switch
While baby products are safe, they may eventually become less effective for older children:
| Product | Why it might stop working | Better Alternative |
|---|---|---|
| Shampoo | Baby shampoo is very mild because babies don't produce much oil. Older kids (ages 7+) who play sports or have thicker hair may find it doesn't clean playground dirt or scalp oils well enough. | Kids’ 2-in-1 Shampoo (slightly stronger cleaning power but still mild) |
| Lotion | Baby lotions are often very light and water-based. Older kids spending hours outdoors may need more heavy-duty hydration. | Ceramide-rich creams (like CeraVe or Aveeno) for better barrier protection |
| Body Wash | Baby wash is often soap-free. As puberty approaches, it may not be strong enough to handle body odor. | Unscented “Sensitive Skin” bars or liquid soaps |
The "Golden Rule" for Ingredients
If you do decide to move away from baby products, look for these "safety markers" on labels to ensure the new products are still kid-friendly:
- Fragrance-Free: Not just "unscented," which can contain masking scents.
- Dye-Free: Avoids unnecessary synthetic colors.
- Sulfate-Free: Especially in shampoos to prevent drying out their hair.
Pro Tip: Baby wipes and baby detergent are actually some of the best products to keep using long-term. Many adults even use baby detergent for their own laundry if they have sensitive skin!
